Time: 1:30-4:00 pm , Oct. 10th, 2017, Tuesday Venue: Room 300, SIBS Main Building, Yueyang Road 320 Host: Prof. Gang Wei CAS-MPG Partner Institute for Computational Biology Title: CTCF is a critical player in controlling gene expression noise
Abstract: Recent studies indicate that even a homogeneous population of cells exhibit substantial cell-to-cell variation in gene expression. Our previous single-cell DNase-seq analysis suggests that chromatin states underlie the gene expression heterogeneity across different cells. CTCF is a key protein in chromatin organization in mammalian cells. I will present data to show that the enhancer-promoter interaction mediated by CTCF plays a critical role in controlling gene expression and reducing cell-to-cell variation of expression.
Bio: Dr. Zhao’s research focuses on the epigenetic regulation of chromatin. Understanding how epigenetic patterns are established during development and how improper epigenetic signals contribute to disease is the long-term goal for his lab. His lab developed the ChIP-SAGE, ChIP-Seq, MNase-Seq, and scDNase-seq techniques and also developed corresponding algorithms to analyze these data. Using these approaches, Dr. Zhao’s lab has been pioneering whole-genome analyses of chromatin modifications in higher eukaryotic systems. By identifying these genome-wide epigenetic patterns, Dr. Zhao’s research has revealed numerous insights into the relationship between the epigenome, chromatin-modifying enzymes, and gene expression.
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