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PICB Seminar: CTCF is a critical player in controlling gene expression noise by Dr. Keji Zhao
2017-09-27
 

Speaker: Keji Zhao, PhD
                Director and Senior Investigator, Systems Biology Center,
                National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH)
                Web:
https://www.nhlbi.nih.gov/research/intramural/researchers/pi/zhao-keji/

Time: 1:30-4:00 pm , Oct. 10th, 2017, Tuesday
Venue: Room 300, SIBS Main Building, Yueyang Road 320
Host: Prof. Gang Wei
          CAS-MPG Partner Institute for Computational Biology
Title: CTCF is a critical player in controlling gene expression noise

Abstract:
Recent studies indicate that even a homogeneous population of cells exhibit substantial cell-to-cell variation in gene expression. Our previous single-cell DNase-seq analysis suggests that chromatin states underlie the gene expression heterogeneity across different cells. CTCF is a key protein in chromatin organization in mammalian cells. I will present data to show that the enhancer-promoter interaction mediated by CTCF plays a critical role in controlling gene expression and reducing cell-to-cell variation of expression.

Bio:
Dr. Zhao’s research focuses on the epigenetic regulation of chromatin. Understanding how epigenetic patterns are established during development and how improper epigenetic signals contribute to disease is the long-term goal for his lab. His lab developed the ChIP-SAGE, ChIP-Seq, MNase-Seq, and scDNase-seq techniques and also developed corresponding algorithms to analyze these data. Using these approaches, Dr. Zhao’s lab has been pioneering whole-genome analyses of chromatin modifications in higher eukaryotic systems. By identifying these genome-wide epigenetic patterns, Dr. Zhao’s research has revealed numerous insights into the relationship between the epigenome, chromatin-modifying enzymes, and gene expression.

All are welcome, and anyone who would like to have a talk with speaker, please feel free to contact Jing MU via mujing@picb.ac.cn.

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